Liam M. Longo

An unresolved question in the origin and evolution of life is whether a continuous path from geochemical precursors to the majority of molecules in the biosphere can be reconstructed from modern-day biochemistry. Here we identified a feasible path by simulating the evolution of biosphere-scale metabolism, using only known biochemical reactions and models of primitive coenzymes. We find that purine synthesis constitutes a bottleneck for metabolic expansion, which can be alleviated by non-autocatalytic phosphoryl coupling agents. Early phases of the expansion are enriched with enzymes that are metal dependent and structurally symmetric, supporting models of early biochemical evolution. This expansion trajectory suggests distinct hypotheses regarding the tempo, mode and timing of metabolic pathway evolution, including a late appearance of methane metabolisms and oxygenic photosynthesis consistent with the geochemical record. The concordance between biological and geological analyses suggests that this trajectory provides a plausible evolutionary history for the vast majority of core biochemistry

Understanding the emergence and evolution of agency is one of the great challenges in both biological research and philosophy. Hiroki Kojima (University of Tokyo), Eran Agmon (University of Connecticut), and I will bring agential studies into the laboratory by constructing a real-time evolution platform in which populations of organic (B-life) and digital (A-life) organisms are under mutual control and poised to form mutualistic community structures. Will community structure promote the emergence of agential features in the A-life population? Stay tuned! Calls for two open positions in Tokyo (Longo Lab) and one open position in Connecticut (Agmon Lab with support mentorship from Co-I Kojima) will follow shortly.

After a brief stint at her home institution in Stockholm, Marina has returned to the Longo Lab to continue her research on the evolution of exon structure (and provide some much needed programming mentorship to all those around her). Welcome back, Marina!

Prof. Gruić Sovulj is an expert in the enzymology of amino-acyl tRNA synthetases, the enzymes that define the genetic code. During her 2-month visit to the Longo Lab at ELSI, she will use bioinformatic approaches to study the evolution of this most important enzyme class.

Tatsuya received a Bachelor's degree in Biological Chemistry from the University of Toronto. As a student in the ELSI Graduate Program, his research efforts will focus on the origin of life and the emergence of complex biopolymer structure. Welcome, Tatsuya!

My passion for science started with Science Fair, and so it was a great pleasure to be able to share my research on early protein evolution with these amazingly talented young scientists! Image credit: ELSI

Marina (left) is a Mathematics PhD student working in the laboratory of Lars Arvestad where she studies the evolution of exon duplication. At ELSI, she will explore the consequences of exon duplication from the perspective of protein structure evolution.

Sarah (right) is a Bioinformatics PhD student working in the laboratory of Peter Stadler where she develops methods for RNA structure prediction. At ELSI, she will study the forces that drive protein sequence convergence between distantly related species.